Professor, School of Behavioral Sciences, Tel Aviv-Yaffo College, Israel. Adjunct Professor, College of Pharmacy, University of Minnesota. Adjunct Professor, Dept of Clinical Biochemistry & Pharmacology, Ben-Gurion University of the Negev.
2011 – Present Associate Professor, School of Behavioral Sciences, Tel Aviv-Yaffo College, Israel.
2008 – 2011 Associate Professor, University of Minnesota, College of Pharmacy.
2009 – 2010 Visiting Associate Professor, Tel-Hai College, Israel.
2004 – 2008 Assistant Professor, University of Minnesota, College of Pharmacy.
2001 – 2004 Fellow, Laboratory of Molecular Pathophysiology, NIMH.
Ph.D. (2001) Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheba, Israel.
and Behav. Sci. (1995) Department of Neuroscience and Behavioral Sciences, McMaster University, Hamilton, Ontario, Canada.
M.Sc. in Zoology (1991) Department of Zoology, Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, Israel.
B.Sc. in Biology (1989) Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, Israel.
B.Med.SC. (1985) Faculty of Health Sciences, Hebrew University of Jerusalem Israel.
Main Research Projects:
Autophagy and affective disorders: Autophagy is a process by which cells regulate degradation of aggregate proteins and toxic materials. Enhancement of autophagy therefore results in increased cellular plasticity and resilience and autophagy had been implicated in a number of neurodegenerative disorders. With the emerging concepts suggesting that affective disorders are highly related to processes of cellular strength and plasticity, this project is designed to explore the relationship between autophagy and affect and explore the possibility that autophagy enhancement can be utilized as a potential new target for the development of novel treatments.
Circadian rhythms and depression: Significant data shows relationship between circadian rhythms and depression however the underlying mechanisms of these interactions are far from being understood. In Collaboration with Prof. Noga Kronfeld-Schor at Tel-Aviv University, we have developed a novel approach to study these interactions utilizing a unique model in a diurnal rodent. Our current project is designed to gain further understanding of the relationship between circadian manipulations and affective-like changes at the behavioral and molecular levels.
Individual variability in animal models: when animals are exposed to an intervention, there is a range of responses within a group. This is correct when we induce a model and this is also correct in the responses of the model to drugs. We are currently interested in utilizing the variability in responses in models and treatments of affective disorders as a way to further understand the development of these disorders in humans and the range of therapeutic effects of the drugs in patients.
Recent publications (5 years):
1. Kara NZ, Karpel O, Toker L, Agam G, Belmaker RH, Einat H (2014) Chronic oral carbamazepine treatment elicits mood stabilizing effects in mice. Acta Neuropsychiatrica, 26(1):29-34.
2. Toker L, Kara NZ, Hadas I, Einat H, Bersudsky Y, Belmaker RH, Agam G (2013) Acute ICV Inositol Does Not Reverse the Effect of Chronic Lithium Treatment in the Forced-Swim Test. Neuropsychobiology, 68(3):189-192.
3. Kara NZ, Einat H (2013) Rodent models for mania: practical considerations. Cell & Tissue Research (Special Issue, Rodent Models of Psychiatric Disorders - Practical Considerations), 354(1):191-201.
4. Kara NZ, Agam G, Anderson GW, Belmaker RH and Einat H (2013) Trehalose induced antidepressant-like effects and autophagy enhancement in mice. Psychopharmacology, 229(2): 367-75.
5. Krivisky K, Einat H*, Kronfeld-Schor N (2012) Effects of morning compared with evening bright light administration to ameliorate short-photoperiod induced depression- and anxiety-like behavior in a diurnal rodent model. Journal of Neural transmission (Special issue, Depression), 119(10): 1241-8. *Corresponding author.
6. Juetten J, Einat H (2012) Behavioral differences in black Swiss mice from separate colonies: implications for modeling domains of mania. Behavioural Pharmacology, 23(2): 211-214.
7. Kronfeld-Schor N, Einat H (2012) Circadian rhythms and depression: Human Psychopathology and Animal Models. Neuropharmacology, 62(1): 101-114 (Special issue, Anxiety & Depression).
8. Koss WA, Einat H, Schloesser RJ, Manji HK, Rubinow DR (2012) Estrogen effects on the forced swim test differ in two outbred rat strains. Physiology & Behavior, 106:81-86.
9. Flaisher-Girnberg S, Einat H (2011) Amphetamine-induced conditioned place preference test and modeling domains of bipolar disorder. Open Journal of Neuropsychopharmacology, 4:18-24.
10. Hannah-Poquette C, Anderson G. W, Flaisher-Grinberg S, Wang J. Meinerding T.M, Einat H (2011) Modeling mania: Modeling mania: further validation for Black Swiss mice as model animals. Behavioural Brain Research, 223(1): 222-226.
11. Krivisky K, Ashkenazy T, Kronfeld-Schor N, Einat H (2011) Antidepressants reverse short photoperiod-induced depression-like behavior in the diurnal fat sand rat: further support for the utilization of diurnal rodents for modeling affective disorders. Neuropsychobiology, 63: 191-196
12. Flaisher-Grinberg S, Gampetro DR, Kronfeld-Schor N, Einat H (2011) Inconsistent effects of photoperiod manipulations in tests for affective-like changes in mice: implications for the selection of appropriate model animals. Behavioural Pharmacology, 22(1): 23-30.
13. Wang J, Flaisher-Grinberg S, Li S, Liu H, Sun L, Zhou Y, Einat H (2010) Antidepressant-like effects of the active acidic polysaccharide portion of ginseng in mice. Journal of Ethnopharmacology, 132: 65-69.
14. Flaisher-Grinberg S & Einat H (2010) Strain-specific battery of tests for separate behavioral domains of mania. Frontiers in Psychiatry, 1(10):1-10.
15. Ashkenazy-Frolinger T, Kronfeld-Schor N, Jeutten J, Einat H (2010) It is darkness and not light: depression-like behaviors of diurnal unstriped Nile grass rats maintained on a short daylight schedule. Journal of Neuroscience Methods, 186: 165-170.
16. Flaisher-Grinberg S, Krondfeld-Schor N, Einat H (2010) Models of mania: from facets to domains and from animal models to model animals. Journal of Psychopharmaclogy, 24(3):437-438.
17. Einat H, Belmaker RH, Anderson GW (2010) Response to “mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists". Science e-letters, http://www.sciencemag.org.libpdb.d.umn.edu:2048/content/329/5994/959/reply#content-block.
18. Einat H (2010) Strategies for the development of animal models for bipolar disorder: new opportunities and new challenges. In: Zarate C, Manji H (eds) Behavioral Neurobiology of Bipolar Disorder and its Treatment. Current Topics in Behavioral Neuroscience Vol 5, Springer, Berlin. PP. 69-88.
19. Einat H & Kronfeld-Schor N (2009) Utilizing diurnal model animals in the study of depression. Frontiers in Neuroscience, 3(2): 242-243.
20. Flaisher-Grinberg S & Einat H (2009). Mice models for the manic pole of bipolar disorder. In: Gould TD: Mood and anxiety related phenotypes in mice. Springer Press, Berlin. pp. 297-326.
21. Flaisher-Grinberg S & Einat H (2009) A possible utilization of the mice forced swim test for modeling manic-like increase in vigor and goal-directed behavior. Journal of Pharmacological and Toxicological Methods;59:141-145.
22. Ashkenazy T, Einat H, Kronfeld-Schor N (2009) Effects of bright light treatment on depression- and anxiety-like behaviors of diurnal rodents maintained on a short daylight schedule. Behavioural brain Research; 201: 343-34.
23. Flaisher-Grinberg S, Overgaard S, Einat H (2009) Sweet solution preference modeling the reward seeking domain of mania: face and predictive validity. Journal of Neuroscience Methods. 177(1): 44-50.
24. Ashkenazy T, Einat H, Kronfeld-Schor N (2009) We are in the dark here: induction of depression- and anxiety-like behaviors in the diurnal fat sand rat, by short daylight or melatonin injections. Int. J. Neuropsychopharmacol. 12(1) 83-93.
25. George A & Einat H (2008) Positive attitude change towards psychiatry treatment and patients following an active learning, advanced course in psychopharmacology. Academic Psychiatry. 32,(6) 515-517.
26. Lien R, Flaisher-Grinberg S, Cleary C, Hejny M, Einat H (2008) Behavioral effects of Bcl-2 deficiency: implications for affective disorders. Pharmacological Reports 60:490-498.
27. Cleary C, Linde J.A.S, Hiscock K.M, Hadas I, Belmaker R.H, Agam G, Flaisher-Grinberg S, Einat, H (2008) Antidepressive-like effects of rapamycin in animal models: implications for new targets for treatment of affective disorders. Brain Research Bulletin 76:469-473.
28. Whirley BK & Einat H (2008) Taurine trials in animal models offer no support for anxiolytic, antidepressant or stimulant effects. Israel J of Psychiatry (special issue on Alternative and complementary treatments in psychiatry) 45(1): 11-18.
29. Einat H, Tian F, Belmaker RH, Frost JW (2008) myo-Inositol-1-phosphate (MIP) synthase inhibition: in-vivo study in rats. Journal of Neural Transmission 115(1): 55-58.
30. Large CH, Einat H, Mahableshwarkar AR (2008). Developing therapeutics for bipolar disorder: From animal models to the clinic. In: Mcarthur RA & Borsini F: Animal and translational models for CNS drug discovery. Volume 1, Elsevier, Amsterdam. pp 263-300.
31. Bodner E & Einat H (2008) Efforts to Support Special-Needs Soldiers Serving in the Israeli Defense Forces: Drs Bodner and Einat reply. Psychiatric Services 59(3): 329-330.